There was a recent study by Dr Frye on oxidative stress, inflammation and GI issues in ASD vs control. I am fairly up to date with the research on chronic inflammation and microglial activation in ASD, but it is hard to do same test which are usually available in research settings only (Dr Frye used the 3CT marker for inflammation in his research, we have tested an indirect marker neopterin). While I do believe the gut-brain connection, my question was with respect to specific anti-inflammatory therapies (aside from diet which is important as well if there are food sensitivities/high immune response). So, things such as COX-2 inhibitors such as NSAID, curcumin, etc. Haven't focused on this yet.

Our family is in the process of gathering data from 2 clinics one is a Comprehensive GI profile DNA testing.. Yes we first had to establish that there is inflammation present and in 2 of my children and my self tested there is. We are using a variation of Pro-biotics and Nystatins, and Detox regimints. to reduce inflammation that is believed to be triggered by bad bacteria and up the good bacteria\, another instight from science is they are finding that the Gut and the brain are always in communication with one another, and what triggers diseases? many children on the spectrum have compromised GI tracks I say we start giving that a good hare look and study .. It will take many parents and lots of test to get that control group of Autistic children, all symptomatic with GI issues, and prove them all having markers of inflammation ,In General Health CLinics enforce the concept is to restore the gut. with pro biotics, We were encouraged to do Chelation and I did not do that on my daughter due to the levels were insignificant. She had tummy issues at he time and I did not want to inflict more strain More often you will encounter Doctors who think, this biomed neuroinflamnatoin or immunology is not a valid scientific proven,it is psudo-science. They will discourage it, due to fact that science is yet to prove it out. I have a LOT of data on my own children that apply to us. we are still information gathering and even proving the validity of the testing sites. It is a lot of work. but perhaps some day thinking out side the box, will pay off, it is necessary to look at issues Dr's put in boxes and label for us to handle strictly with medications they are practicing with. When we the parent are consistently dealing with an issue and the meds don't work we do have permission to search, research and develop for our children, I can give you specifics of the data testing in another contact if you wish. Kind Regards.

Regarding Constipation issues Pro-biotics - Beet Kavas,- Smooth move tea, add sweetner to it and make an ice tea the veggies are hard to get in the diet sneak spinach and greens in smoothies add the omega 3's ,Water Water Water too..adding flax seed and fish oil are great some use mineral oils. soak in ebsom salt and some take Ebsom salt to relieve constipation follow the insturctions on the box. Recently we have been going to Born Clinic in Grand Rapids Michigan and the Gleason Center in Fremont Mi... I have suppliments we follow all according to there own specific GI profiles.. Keep using Pro- biotics like acidophilus and ALIGN, some yougerts and Milk products can add to constipation that is where the testing is benificial.

That should be acetyl-l-CARNITINE, not choline.

I read Dr. Goldberg's book and found it very interesting. However, my DD did not fit his NIDS profile at all. So while I think he may be onto something for a subset of kids with ASD, it isn't relevant for my own family. That said, my DD has responded very well to supplements that reduce oxidative stress like Coenzyme Q10 and acetyl-l-choline and she became worse when we tried the low-phenol diet (which is also low in antioxidants). So I definitely think they are worth trying to see if they help any.