Gene editing offers a promising avenue for autism research and potential treatment, with ongoing studies exploring various techniques and targeting specific genes. While challenges and ethical considerations remain, advancements in this field could offer hope for individuals with autism and their families

Key areas of research and potential applications:
Targeting specific genes:
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Researchers are focusing on genes like MEF2C, which is strongly linked to autism, and others like CHD8, which has been implicated in autism spectrum disorder.
Correcting mutations:
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CRISPR-based methods are being used to correct disease-causing mutations in these genes, potentially reversing the associated developmental issues, speech impairments, and repetitive behaviors.
Restoring protein levels:
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Studies have shown success in restoring protein levels in mice with autism-like mutations, leading to a reversal of behavioral abnormalities.
Regulating gene expression:
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Research is also exploring the use of CRISPR to activate or suppress genes, potentially counteracting the effects of harmful gene variants.
Developing gene therapies:
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Several companies are developing gene therapies for autism, with some focusing on specific genetic forms of the disorder, like Phelan-McDermid syndrome.
Clinical trials:
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A gene therapy for a targeted genetic form of autism, JAG201, is in clinical trials with patient enrollment anticipated to begin in Q1 2025

I used to live near NIH so I have been following there (see link)

https://pmc.ncbi.nlm.nih.gov/articles/PMC10237133/

Modernising autism spectrum disorder model engineering and treatment via CRISPR-Cas9: A gene reprogramming approach

https://pmc.ncbi.nlm.nih.gov/articles/PMC10237133/