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Real members of MyAutismTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyAutismTeam Member asked a question 💭
Toronto, ON

New study out showing MB12 shot with folinic acid efficacy tied to glutathione redox status (GSH/GSSG). Glutathione is the main antioxidant of the body.

http://www.hindawi.com/journals/aurt/2013/609705/

Significant correlation and efficacy seen with respect to expressive communication and social skills. For us, it had immediate and noticeable impact and we do see a lot more expressive communication after shot. We use methyl folate instead of folinic acid. Another study has shown roughly a… read more

October 16, 2013
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Answer Summary

Members discussed dosing strategies for methylB12 injections in children with autism, with many following a study protocol of 75mcg per... Read more

Members discussed dosing strategies for methylB12 injections in children with autism, with many following a study protocol of 75mcg per kilogram every three days rather than weekly shots, as the water-soluble vitamin is quickly excreted and needs consistent availability throughout the day. Several members shared practical dosing calculations for their children's weight, emphasized the importance of correcting prescriptions with doctors when dosages seemed too high, and noted that effects typically last one to two days, which is why some families opt for every-other-day or daily injections rather than the original three-day protocol. A recurring theme was the value of methyl folate supplementation alongside MB12, the challenge of administering subcutaneous shots at the correct steep angle for slow release, and the reassurance that excess MB12 has no known toxicity since it is naturally excreted in urine.

A MyAutismTeam Member

Interesting. My DD is on mB12 but not folinic acid/Leucovorin. She is however taking 5MTHF, which is a different bioactive form of folate.

October 16, 2013
A MyAutismTeam Member

My son takes mb12 shots on daily with folinic acid for 1 month. Now, he starts glutathione.

January 18, 2017
A MyAutismTeam Member

Yeah I read a lot of Dr. Neubrander's research. I wish we lived nearer to his office and he could see Logan. we do give the shot at a steep angle. well in order not to waste the prescription I have left, I will try the half of the dose every 3 days and then get the new prescription corrected. thanks for the info.

October 18, 2013
A MyAutismTeam Member

Our son was around 37lbs when we got the script and 3 years old. It isn't the high dosage that matters for MB12 as much as constant availability of MB12 throughout the day (don't need much for that). The original protocol by Dr Neubrander was to give sub-cutaneous shot at steep angle, so the dose would be slowly released into the blood stream and effect could last up to 3 days - that is very hard to do consistently which is why some parents do daily shots.

October 18, 2013
A MyAutismTeam Member

Although there is no known toxicity with MB12 given water soluble and any excess is excreted anyway, I would still try to correct dosage from the doctor, or get the pharmacy to call your doctor's office to correct dosage as he may have calculated based on lbs, not kg. I would try to get the RX fixed and do it correctly per the study.

October 18, 2013

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